Severe acute flaccid myelitis associated with enterovirus in children: two phenotypes for two evolution profiles?

Publié le 28 avril 2020
Mis à jour le 19 mai 2021

Acute flaccid myelitis (AFM) is an acute paralysis syndrome defined by a specific inflammation of the anterior horn cells of the spinal cord. From 2014, worrying waves of life-threatening AFM consecutive to enterovirus infection (EV-D68 and EV-A71) have been reported. We describe 10 children displaying an AFM with an EV infection, the treatments performed and the 1 to 3-years follow-up. Two groups of patients were distinguished: 6 children ("polio-like group") had severe motor disability whereas 4 other children ("brainstem group") displayed severe brainstem weakness requiring ventilation support. Electrodiagnostic studies (n = 8) support the presence of a motor neuronopathy associated to myelitis. The best prognosis factor seems to be the motor recovery after the first 4 weeks of the disease.

Auteur : Aubart Melodie, Gitiaux Cyril, Roux Charles Joris, Levy Raphael, Schuffenecker Isabelle, Mirand Audrey, Bach Nathalie, Moulin Florence, Bergounioux Jean, Leruez-Ville Marianne, Rozenberg Flore, Sterlin Delphine, Musset Lucile, Antona Denise, Boddaert Nathalie, Zhang Shen Ying, Kossorotoff Manoelle, Desguerre Isabelle
Frontiers in Neurology, 2020, vol. 11, p. 1-7