OBJECTIVE: Despite regular follow-up, men who have sex with men (MSM) taking PrEP (Pre-Exposure Prophylaxis) have suboptimal human papillomavirus (HPV) vaccination rates. We aimed to identify the barriers and levers to HPV vaccination among this population. DESIGN: A cross-sectional online survey collected quantitative data on HPV vaccination and PrEP use from 3730 French MSM; 29 qualitative interviews were also conducted between February and August 2022. METHODS: Quantitative analyses were restricted to the 354 MSM under 32 years old (i.e., individuals who were currently or had previously been eligible for HPV vaccination reimbursement) who took PrEP. The HPV vaccination rate was calculated and the associated factors were estimated by a Poisson regression model. Ten of the 29 qualitative interviews were analysed to study PrEP users" perceptions of the levers and barriers to HPV vaccination. RESULTS: The HPV vaccination coverage rate was 71.2 %. MSM who were recommended vaccination by a physician and those who felt comfortable talking about vaccination with their physician were more likely to be vaccinated than the others. The interviews underlined that persistent missed opportunities for HPV vaccination were linked to less close and trustful relationships with physicians, essential factors in being able to discuss sexuality, and therefore to receive appropriate vaccination recommendations. CONCLUSION: The HPV vaccination coverage rate in French MSM who take PrEP is below the 80 % target. Including HPV vaccination in PrEP management recommendations, and improving the training of physicians on MSM health issues are essential measures to enhance vaccine coverage.
Auteur : Annequin Margot, Mora Marion, Fressard Lisa, Cogordan Chloé, Brosset Emeline, Bocquier Aurélie, Velter Annie, Bourrelly Michel, Constance Jean, Michels David, Costa Marie, Morel Stéphane, Girard Gabriel, Oliveri Camilla, Maradan Gwenaëlle, Berenger Cyril, Spire Bruno, Verger Pierre
Vaccine, 2025, vol. 56, p. 127190
