Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017

Publié le 24 Mai 2018
Mis à jour le 18 octobre 2019

We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.

Auteur : Poncin Thibault, Fouere Sebastien, Braille Aymeric, Camelena Francois, Agsous Myriem, Bebear Cecile, Kumanski Sylvain, Lot Florence, Mercier-Delarue Severine, Ngangro Ndeindo Ndeikoundam, Salmona Maud, Schnepf Nathalie, Timsit Julie, Unemo Magnus, Bercot Beatrice
Eurosurveillance, 2018, vol. 23, n°. 21, p. 1-3