MCR-1 and OXA-48 in vivo acquisition in KPC-producing Escherichia coli after colistin treatment

Publié le 1 Juillet 2017
Mis à jour le 5 juillet 2019

The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.

Auteur : Beyrouthy R, Robin F, Lessene A, Lacombat I, Dortet L, Naas T, Pontiès V, Bonnet R
Antimicrobial Agents and Chemotherapy, 2017, vol. 61, n°. 8, p. pii: e02540-16