BACKGROUND: Pneumococcal conjugate vaccines (PCVs) that are ten-valent (PCV10) and 13-valent (PCV13) became available in 2010. We evaluated their global impact on invasive pneumococcal disease (IPD) incidence in all ages. METHODS: Serotype-specific IPD cases and population denominators were obtained directly from surveillance sites using PCV10 or PCV13 in their national immunisation programmes and with a primary series uptake of at least 50%. Annual incidence rate ratios (IRRs) were estimated comparing the incidence before any PCV with each year post-PCV10 or post-PCV13 introduction using Bayesian multi-level, mixed-effects Poisson regressions, by site and age group. All site-weighted average IRRs were estimated using linear mixed-effects regression, stratified by product and previous seven-valent PCV (PCV7) effect (none, moderate, or substantial). FINDINGS: Analyses included 32 PCV13 sites (488 758 cases) and 15 PCV10 sites (46 386 cases) in 30 countries, primarily high income (39 sites), using booster dose schedules (41 sites). By 6 years after PCV10 or PCV13 introduction, IPD due to PCV10-type serotypes and PCV10-related serotype 6A declined substantially for both products (age
Auteur : Bennett Julia C, Deloria Knoll Maria, Kagucia Eunice W, Garcia Quesada Maria, Zeger Scott L, Hetrich Marissa K, Yang Yangyupei, Herbert Carly, Ogyu Anju, Cohen Adam L, Yildirim Inci, Winje Brita A, von Gottberg Anne, Viriot Delphine, van der Linden Mark, Valentiner-Branth Palle, Suga Shigeru, Steens Anneke, Skoczynska Anna, Sinkovec Zorko Nadja, Scott J Anthony, Savulescu Camelia, Savrasova Larisa, Sanz Juan Carlos, Russell Fiona, Ricketson Leah J, Puentes Rodrigo, Nuorti J Pekka, Mereckiene Jolita, McMahon Kimberley, McGeer Allison, Mad'arová Lucia, Mackenzie Grant A, MacDonald Laura, Lepp Tiia, Ladhani Shamez N, Kristinsson Karl G, Kozakova Jana, Klein Nicola P, Jayasinghe Sanjay, Ho Pak-Leung, Hilty Markus, Heyderman Robert S, Hasanuzzaman Md, Hammitt Laura L, Guevara Marcela, Grgic-Vitek Marta, Gierke Ryan, Georgakopoulou Theano, Galloway Yvonne, Diawara Idrissa, Desmet Stefanie, De Wals Philippe, Dagan Ron, Colzani Edoardo, Cohen Cheryl, Ciruela Pilar, Chuluunbat Urtnasan, Chan Guanhao, Camilli Romina, Bruce Michael G, Brandileone Maria-Cristina C, Bigogo Godfrey, Ampofo Krow, O'Brien Katherine L, Feikin Daniel R, Hayford Kyla
The Lancet. Infectious diseases, 2024, p. Online ahead of print
