Background: migrant populations are overrepresented among persons diagnosed with HIV in the European Union (EU) and the European Economic Area (EEA). Understanding the timing of HIV acquisition (pre- or post-migration) is crucial for developing public health interventions and for producing reliable estimates of HIV incidence and the number of people living with undiagnosed HIV infection. We summarize a recently proposed method for determining timing of HIV acquisition and apply it to both real and simulated data. Methods: the considered method combines estimates from a mixed model, applied to data from a large seroconverters cohort, with biomarker measurements and individual characteristics to derive probabilities of pre-migration HIV acquisition within a Bayesian framework. The method is applied to a subset of data from The European Surveillance System (TESSy) and simulated data. Findings: simulation study results showed good performance with the probabilities of correctly classifying a pre-migration or a post-migration case being 87.4% and 80.4%, respectively. Applying the method to TESSy data, we estimated the proportions of migrants who acquired HIV in the destination country were 31.9%, 37.1%, 45.3% and 45.2% for those originating from Africa, Europe, Asia and other regions, respectively. Conclusions: although the considered method was initially developed for cases with multiple biomarkers" measurements, its performance when applied to data where only one CD4 count per individual is available, remains satisfactory. Application of the method to TESSy data, estimated that a substantial proportion of HIV acquisition among migrants occurs in destination countries, having important implications for public health policy and programmes.
Auteur : Pantazis Nikos, Rosinska Magdalena, Van Sighem Ard, Quinten Chantal, Noori Teymur, Burns Fiona, Cortes Martins Helena, Kirwan Peter D, O'Donnell Kate, Paraskevis Dimitrios, Sommen Cécile, Zenner Dominik, Pharris Anastasia
Journal of Acquired Immune Deficiency Syndromes, 2021, p. 1-25
