Introduction - In France, the underreporting rate for carpal tunnel syndrome (CTS)—the second most commonly recognized occupational disease—was estimated at 43% in 2015. The objective was to determine the attributable risk fractions for CKS (FRAE) among exposed individuals, within high-risk occupations and economic sectors. Materials and Methods - Data on patients who underwent surgery for CKS from two studies conducted in Maine-et-Loire (2002–2003) and in Bouches-du-Rhône (2008–2009) were compiled to calculate the FRAE for occupations or economic sectors (employment status at the time of surgery) among patients exposed to them. The calculation was based on determining the age-adjusted relative risk for the occupation or sector using the Mantel-Haenszel method. Results—Among male and female manual workers, three-quarters of SCC cases are attributable to the excess risk associated with their occupation. The economic sectors with the highest FRAE for SCC were the leather and footwear industry among men (FRAE = 93%) and the automotive industry among women (FRAE = 89%). For specific occupations, these were skilled roofers among men (work-attributable risk fraction = 97%) and female workers in market gardening and horticulture among women (work-attributable risk fraction = 94%). Within the same industry sector, certain occupations had higher work-attributable risk fractions than others, even in sectors that did not show an overall excess risk of SCC. Discussion - Calculating FRAEs for different economic sectors and/or SCC occupations—when such calculations are possible—allows for the identification of high-risk jobs and thus helps target these jobs for workplace prevention initiatives, complementing occupational disease statistics.