Key Points

• A slight increase in pediatric HUS cases reported to Santé publique France in 2025 compared to 2024, though the total remains lower than the number of cases reported during the 2017–2023 period:
  • 109 cases in 2025 versus 87 in 2024
  • Annual incidence of 1.0 cases per 100,000 children under 15
• Incidence rate among children under 3 years of age has returned to its usual level:
  • 4.0 cases per 100,000 children in 2025 versus 1.8 cases per 100,000 children in 2024
• A significant number of suspected clusters of infections in daycare centers (7 investigations), including an outbreak affecting 12 children, 2 of whom developed HUS