The fight against antibiotic resistance is an issue on par with the environmental challenges of our time. Since 2015, the World Health Organization has been guiding its actions through a "One Health" approach, promoting the integration of prevention efforts across human health, animal health, and the environment. In France, antibiotic consumption in human healthcare has been declining since 2016. The European Antibiotic Awareness Day on November 18, 2019, is part of World Antibiotic Awareness Week and mobilizes all stakeholders: citizens, patients, human and animal healthcare professionals, and decision-makers. To this end, since 2014, three national agencies—Public Health France, the National Agency for Medicines and Health Products Safety (ANSM), the French Agency for Food, Environmental and Occupational Health & Safety (ANSES)—as well as the French National Health Insurance and their respective ministries—have been joining forces with their partners to jointly present key figures on antibiotic consumption and resistance from a global health (“One Health”) perspective.