Key Points

• In Week 04 (January 25–31, 2021), epidemiological monitoring indicators showed a further increase in SARS-CoV-2 circulation.

• According to the departments of the Île-de-France region, disparities in epidemiological indicators are observed amid a rise in the prevalence of variants known to be more transmissible.

• At this stage, single-dose vaccination coverage in Île-de-France is estimated at 59.5% among the target population and 1.8% in the general population.