In 2019, compared to the rest of France, the population of the Grand Est region was characterized by: • A higher reported lifetime incidence of bites (46% vs. 29%) • More reported bites in the past twelve months (11% vs. 5%) • Bites occurring mainly in forests (68%) followed by gardens (14%) • Greater use of tick removers (72% vs. 65%) • A stronger sense of exposure (35% vs. 24%) • Higher frequency of use of recommended protective measures • Greater awareness of Lyme disease (90% vs. 78%) • Higher level of information (58% vs. 40%) • Greater concern about contracting the disease (28% vs. 18%) Compared to 2016 data, the population of the Grand Est region is characterized by: • More reported bites in the past 12 months (8% vs. 12%) • More frequent wearing of long clothing (73% vs. 82%) • Greater awareness of Lyme disease (85% vs. 90%)