This article describes the development, implementation, and effectiveness of the Jobs program, an evidence-based psychosocial intervention centered on peer learning. This program aims to support unemployed individuals in their job search while safeguarding their mental health. Job loss often leads to financial difficulties, family tensions, and psychological distress, thereby increasing the risk of depression, particularly in cases of long-term unemployment. Research shows, however, that targeted interventions can strengthen job-search skills, boost motivation, and mitigate the negative emotional consequences of career setbacks. Large-scale randomized trials conducted in the United States have demonstrated significant benefits, including higher rates of re-employment, better job quality, reduced depressive symptoms, and long-term economic benefits. The program was subsequently adapted in Finland under the name “Työhön” and successfully tested among the long-term unemployed, despite differences in social benefits and labor markets. Similar positive results have been reported in several other countries, including the United Kingdom, Germany, Ireland, the Netherlands, South Africa, as well as China and South Korea. We discuss the early research and work conducted at the University of Michigan’s Michigan Prevention Research Center to develop the Jobs intervention for the unemployed. We also describe the program’s subsequent dissemination nationally and internationally.