In 2005, the 22 Regional Pneumococcal Surveillance Centers (ORP) collected 6,398 pneumococcal strains from 6,398 specimens taken from 6,156 patients, of whom 4,303 (69.9%) were adults (A) and 1,853 (30.1%) were children (C). The 6,398 specimens were distributed as follows: 399 CSF samples (A: 288 and C: 111), 4,048 blood cultures (A: 3,562 and C: 486), 1,315 ear pus samples (C: 1,212), and 636 respiratory specimens (A: 521). The percentage of strains classified as intermediate or resistant to penicillin was 44.6% (A: 40.4% and C: 54.3%), 22.4% for amoxicillin (A: 22.4% and E: 28.9%), and 14.6% for cefotaxime (A: 13.1% and E: 17.9%). In CSF, the number of strains with a minimum inhibitory concentration (MIC) greater than 0.25 mg/L was 188 for amoxicillin and 91 for cefotaxime. In the CSF, 42.8% of the serotypes isolated from children are present in the 7-valent vaccine, and 76.4% of the serotypes isolated from adults are present in the 23-valent vaccine. (R.A.)