The full questionnaire for the 2021 Santé publique France Public Health Barometer – DROM is presented here. It covers four departments: Guadeloupe, Martinique, French Guiana, and Réunion. It includes the instructions displayed on the interviewers’ screens as well as the conditions for the questions. These questions cover the following topics: pesticides, including chlordecone; environmental health; smoking cessation; tobacco use during pregnancy; e-cigarettes; cannabis; alcohol consumption during pregnancy; awareness of alcohol consumption guidelines and risks; vaccination; general health; healthcare utilization and non-utilization, diabetes, high blood pressure, COVID-19, mental health, physical activity and sedentary behavior, diet, and housing.