Introduction - The objective of this study is to describe suicide risk by occupation. It is based on data from the pilot phase in the Rhône-Alpes region of the “Samotrace” mental health surveillance program by occupational activity, developed at the French Institute for Public Health Surveillance (InVS). Materials and Methods - The sample was selected by random sampling from a population of employees monitored by a network of approximately 80 occupational physicians between January 2006 and March 2008. Suicide risk was assessed using the Mini diagnostic questionnaire, administered by the occupational physician. Employment was described by occupation and industry sector. Suicide risk is described here by sex, age, socioeconomic status, and industry sector. Results—Suicide risk affects nearly 10% of women and 7% of men. Among men, this risk follows a social gradient, with the most affluent socioeconomic categories being the least affected. Although the results are not statistically significant, the health and social services sector and the transportation and communications sector may be particularly affected. Among women, the variation in suicide risk by occupation is less pronounced. Conclusion—The identification of vulnerable populations, particularly those at high risk of suicide, should lead to the implementation of specific prevention measures. (R.A.)