The Rhône-Alpes Regional Suicide Observatory was established in 2014 to improve understanding of suicide and suicide attempts (SA) in the region. The data presented pertain to suicide mortality, based on databases from the Center for Epidemiology on Medical Causes of Death (Inserm CépiDc), and hospitalizations for suicide attempts recorded in the Medical Information Systems Program for Medicine, Surgery, and Obstetrics (PMSI-MCO). Approximately 800 suicide deaths per year were recorded in the Rhône-Alpes region during the 2010–2012 period. The annual standardized suicide mortality rate was 12.3 per 100,000 inhabitants. Suicides were most common among people aged 45–54 and were more prevalent among men than women. The departments of Ardèche, Drôme, and Loire had the highest rates. In 2014, the standardized rate of hospital admissions for suicide attempts in Rhône-Alpes was 122 per 100,000 inhabitants. This rate was higher among women than among men. It was also higher in the Ardèche and Loire departments than in the region’s other departments. The highest crude rates were recorded among girls aged 15–19 and women aged 45–49. This initial regional assessment of suicide-related mortality and morbidity shows a more favorable situation in Rhône-Alpes than in France as a whole. This study also highlights significant inequalities by age and sex, as well as major regional disparities within the Rhône-Alpes region. To track changes in these disparities and measure the impact of regional suicide prevention policies, these data will be updated annually and systematically compared with national data. Data from the OSCOUR® network will further enrich these findings.