In France, the issue of work-related suicides has been a particularly pressing concern for several years. This phenomenon appears to have increased, although it is not yet possible to quantify it. The objective of this exploratory study is to test the use of existing French data sources (a multi-source system) to estimate the frequency of work-related suicides and to describe them. The study was conducted in two phases: an exploration of available data sources relevant to such surveillance and a pilot study at the regional level. Six potentially usable data sources were identified, four of which are considered major: mortality data from the Center for Epidemiology on Medical Causes of Death (CépiDc), data on workers’ compensation claims from social security systems, reports from forensic medical institutions, and reports from the Labor Inspectorate. Data exploration and the pilot study showed that access to these sources varied in ease, that no single source was exhaustive, and that each had different limitations (population coverage, lack of centralization and computerization of data, underreporting, etc.). Nevertheless, despite these limitations and difficulties, the establishment of a surveillance system could be feasible. Furthermore, one of the sources—forensic medical institutes—appears to be particularly indispensable. However, using this source of information would require the development of a computerized data-recording system, which is not currently in place. (R.A.)