Introduction – Hypertension is the most common chronic disease in France and is responsible for cardiovascular, cerebrovascular, renal, and dementia-related complications. The objective of this study was to estimate the burden of hypertension and its complications in France. Methods – An indirect comparative risk assessment methodology was used to estimate the population-attributable fractions (PAFs) of HTN for each of the conditions causally associated with HTN in adults aged 35 and older. These PAFs were applied to 2021 national statistics on mortality, hospitalizations, and the prevalence of these conditions. Results – In 2021, it was estimated that 36.2% (95% confidence interval, 95% CI: [32.5–41.6]) of hospitalizations for cardiovascular, cerebrovascular, or renal diseases were attributable to hypertension, representing 385,000 patients, 400,000 full hospital stays, and 6.2 million hospital days. More than 1.15 million people were living with ischemic heart disease attributable to hypertension, 1.26 million with chronic kidney disease, and 358,000 with heart failure. In 2021, more than 55,000 deaths were attributable to hypertension, accounting for 8.5% of all deaths in France and nearly 500,000 years of life lost. Discussion – This estimate of the burden attributable to hypertension in France highlights the considerable health impact of hypertension on the French population and the healthcare system. To reduce this burden, it is essential to implement ambitious public health policies targeting both the prevention of hypertension and its screening and management to reduce complications.