Key Points

• Leptospirosis was added to the list of notifiable diseases (MSO) on August 17, 2023.
• From January 1 to December 31, 2025, 562 cases of leptospirosis were reported, including 274 in mainland France and Corsica and 288 in the Overseas Departments and Regions (DROM).
• Of the 562 reported cases, 380 were hospitalized (68%) and 6 died (1%).
• The high proportion of cases requiring admission to the intensive care unit (36% of hospitalized cases) underscores the potential severity of this zoonosis.
• The case notification rate for leptospirosis in mainland France and Corsica was 0.4 cases per 100,000 inhabitants.
• The identified exposures—particularly gardening, farming, and swimming in freshwater—underscore the importance of implementing preventive measures in wet environments that may be contaminated by animals.
• The identification of cases linked to the ownership of exotic pets underscores the importance of raising public awareness about the need to take individual preventive measures when coming into contact with wild and domestic animals, particularly exotic pets (primarily rodents).