The year 2020 brought about significant changes in everyday behavior due to the COVID-19 pandemic and the lockdowns and preventive measures implemented to limit its spread. These changes helped curb the transmission of other infections; they also impacted healthcare utilization and the management of certain human health conditions. Effects were thus observed on antibiotic resistance in human health: primarily on trends in antibiotic consumption, with an unprecedented 18% decrease in antibiotic prescriptions in the outpatient sector, but also on the development of bacterial resistance to antibiotics. Furthermore, 2020 highlighted the role of the environment in the emergence and spread of new infectious diseases, including infections caused by antibiotic-resistant bacteria, and the importance of understanding the ecology of different environments and the factors that may contribute to these outbreaks. In animal health, it is more difficult to attribute the impact of the COVID-19 pandemic on antibiotic resistance; nevertheless, efforts and results achieved through the Ecoantibio initiatives have continued. The two-page infographic in this edition of the antibiotic resistance summary highlights the very significant trends observed in 2020, while noting that France remains in 26th place among the 29 European countries contributing to the ESAC-Net surveillance network. In contrast, it reports on the drastic changes in healthcare utilization and common winter illnesses and highlights the behaviors and practices adopted during the COVID-19 pandemic that protect us and our loved ones. European Antibiotic Awareness Day on November 18, 2021, is part of World Antimicrobial Stewardship Week and mobilizes all stakeholders: citizens, patients, human and animal health professionals, environmental experts, and decision-makers. To this end, since 2014, three national agencies—Santé publique France, the National Agency for Medicines and Health Products Safety (ANSM), the French Agency for Food, Environmental and Occupational Health & Safety (ANSES)—as well as the French National Health Insurance, the French National Authority for Health (HAS), and their respective ministries—have been joining forces with their partners to jointly present key figures on antibiotic consumption and resistance from a global health (“One Health”) perspective. Since 2018, the document has also addressed the role of the environment, in collaboration with the Inserm hospital-university team in Limoges and the Ministry for Ecological Transition.