Common pathogens

Antibiotic-resistant bacterial strains are strains for which there is a high probability of treatment failure regardless of the type of treatment and the dose of antibiotic used. Resistance breakpoints for various antibiotics for each bacterial species are defined annually by the Antibiogram Committee of the French Society of Microbiology (CA-SFM). However, different resistance breakpoints may be used to ensure data comparability with international standards (see Neisseria gonorrhoeae). For antifungals, the interpretation breakpoints used by the CNR are those defined by the CLSI (Clinical and Laboratory Standards Institute) (http://www.clsi.org/) pending those from the EUCAST committee.The table below summarizes the updated data available for the main bacterial species pathogenic to humans, for which resistance phenomena are of public health interest given the treatment failures they may cause.

Click on the name of the pathogen or antimicrobial to access more data.

Pathogen

Main indicator of resistance

% in the species

Year

Geographic coverage

Sources

BACTERIA

Campylobacter coli

erythromycin, ciprofloxacin

864

2017

National

- CNR Campylobacter and Helicobacter - Public Health France

Campylobacter jejuni

erythromycin, ciprofloxacin

< 158

2017

National

- CNR Campylobacter and Helicobacter - Public Health France

Enterococcus faecalis

glycopeptides, ampicillin/amoxicillin (I+R)

< 1< 1

2017

National

- Onerba - CNR-affiliated laboratory for enterococci - CNR for Antibiotic Resistance - Public Health France

Enterococcus faecium

glycopeptides, ampicillin/amoxicillin (I+R)

< 182

2017

national

- Onerba - CNR-affiliated laboratory for enterococci - CNR on antibiotic resistance - Santé publique France

Escherichia coli

3rd-generation cephalosporins, fluoroquinolones, carbapenems

10.3 15.1< 0.1

2017

national

- Onerba - BMR-Raisin - Santé publique France

Haemophilus influenzae

amoxicillin

21.0

2017

national

- CNR Haemophilus influenzae - Public Health France

Klebsiella pneumoniae

3rd-generation cephalosporins, carbapenems

29.0 0.7

2017

national

- Onerba - Public Health France

Mycobacterium tuberculosis complex

multidrug resistance*

1.7

2016

national

- CNR Mycobacteria and Mycobacterial Resistance to Antituberculosis Drugs - Santé publique France

Neisseria gonorrhoeae

ceftriaxone >0.125–0.25 mg/L >0.25 mg/L

00

2016

National

- National Reference Center for Gonococci - Public Health France

Neisseria meningitidis

penicillin G (I+R) rifampicin

300

2017

National

- Meningococcal National Reference Center - Public Health France

Pseudomonas aeruginosa

ceftazidime carbapenems

12,213,9

2017

national

- Onerba - Public Health France

Salmonella enterica serotype Enteritidis

third-generation cephalosporin (children) and ciprofloxacin (adults)

< 1 0

2016

National

- CNR for Salmonella - Public Health France

Salmonella enterica serotype Typhimurium

third-generation cephalosporin (children) and ciprofloxacin (adults)

3.5 0

2016

national

- CNR for Salmonella - Public Health France

Salmonella enterica serotype 1,4,[5],12:i:- (monophasic variant of S. Typhimurium)

third-generation cephalosporin (children) and ciprofloxacin (adults)

2.5 0

2016

national

- CNR for Salmonella - Public Health France

Shigella

ciprofloxacin

azithromycin

13.1

20.6

2017

national

- CNR for Escherichia coli and Shigella - Santé publique France

Staphylococcus aureus

Methicillin

12.9 (in healthcare settings)

2017

national

- Onerba - BMR-Raisin - CNR for Staphylococci - Santé publique France

Streptococcus pneumoniae

penicillin G (I+R) erythromycin (I+R)

25,326,3

2016 Preliminary data

national

- National Reference Center for Pneumococci - Public Health France

Streptococcus pyogenes

erythromycin Adult Child tetracycline

3 3 113

2017

National

- Streptococcus Reference Standards - Onerba - Public Health France

YEAST

Candida albicans

fluconazole, voriconazole

00

2017

regional

- CNR Mycology and Antifungals

Other Candida

fluconazole, voriconazole

see fact sheet

2017

Regional (Ile-de-France)

- CNR Mycology and Antifungals

* combination of resistance to isoniazid and rifampicin.