This publication presents regional statistics drawn from the 2010 Health Barometer in the form of: - a set of maps illustrating the main patterns of psychoactive substance use among the general population and, more specifically, among young adults (ages 15–30) in metropolitan France; - a region-by-region analysis. It also offers a brief overview of data collected by other surveys in the overseas departments. Its aim is to assist public authorities, local stakeholders, and researchers in gaining a better understanding of regional specificities by providing reliable quantitative data on psychoactive substance use in France.