Background : The aim was to describe the association between social inequalities and the prevalence/incidence of pharmacologically-treated type 2 diabetes (T2D) in France over the 2010-2020 period. Methods : Diabetes cases were identified using a validated algorithm in the French national health data system. Analyses were restricted to adults =45 years to focus analyses on T2D. Social inequalities were measured, each year, via the French Deprivation index (FDep) for metropolitan France. Individuals living in the French overseas territories (FOT) were considered in separately group. Age-standardized (2013 European standard population) prevalence and incidence rates were stratified by sex. Denominators were French health consumers (from 24,229,236 in 2010 to 29,772,952 in 2020). Results: Age-standardized T2D prevalence and incidence were higher in most deprived quintiles Q5 compared to the less deprived Q1 in metropolitan France and was even higher in the FOT, for both genders. Q5/Q1 ratio of prevalence and incidence at the beginning of the period for men (1.3 and 1.3 respectively) and women (1.7 and 1.6) increased during the period. In 2020, they met respectively 1.4 and 1.5 for men and 1.8 and 1.7 for women. Conclusion: Social inequalities are positively associated with the prevalence/incidence of pharmacologically-treated T2D in metropolitan France. The association is stronger in women than in men and has increased during the 2010-2020 period. These results will be confirmed using a multivariate model