Introduction – This study describes mortality by underlying and associated causes in 2024.Methods – Using death certificates for residents who died in France, the medical causes of death were coded according to the International Classification of Diseases, 10th Revision (ICD-10), and a primary cause of death was determined. These underlying causes were grouped according to the European list of causes of death. Number of deaths and age-standardized mortality rates were analyzed by cause, age group, and sex. The 2024 rates are compared with those of 2023 and with trend-based mortality levels estimated using a Poisson regression model for the period 2015–2019, with a sensitivity analysis covering the period 2012–2019. The leading causes of death in 2024 are also described. Results – The standardized mortality rate decreased slightly compared to 2023, driven by the decline in mortality due to COVID-19. Conversely, mortality from respiratory diseases is increasing. Mortality from endocrine, nutritional, and metabolic diseases, as well as from diseases of the circulatory, digestive, and genitourinary systems, remains higher than pre-pandemic trends. Nearly one-third of death certificates list at least one associated cause, the profile of which changes with age. Hypertension, arrhythmias and conduction disorders, diabetes mellitus, and neoplasms are the most common associated causes across all age groups.Discussion – This study reports trends consistent with international findings. Beyond the initial cause, associated causes correspond to comorbidities, which constitute risk factors or factors that exacerbate the initial cause.