Despite the significance of post-travel illness, all existing studies have been conducted in settings specializing in infectious diseases or travel medicine. We present a prospective, descriptive survey conducted among volunteer general practitioners (GPs). The study took place over two months (September 2005–January 2006). Of the 123 GPs who participated, 43 included 97 patients. Eighty-six patients were already known to the GP. Health issues following travel accounted for a small portion of their practice (0.4 consultations/GP/month). The average age of patients was 30 years (range 1–78 years). The male-to-female ratio was 0.87. The main destinations were the Maghreb (57%) and Sub-Saharan Africa (17%). The two main reasons for travel were tourism (46%) and migrants returning to their home countries to visit family and friends (43%). The 97 travelers presented with 113 health issues, with 15 travelers seeking consultation for more than one medical problem. The main reasons for consultation were digestive disorders (30%), respiratory disorders (18%), dermatological conditions (11%), and fever (8%). Three patients (3%) presented with an exclusively tropical imported condition (1 dengue, 2 malaria cases). A specialist consultation was requested for eight patients (8%), and one was hospitalized. In conclusion, the conditions observed upon return from travel in private practice are overwhelmingly of cosmopolitan origin. (R.A.)