The results presented here pertain to cases of active tuberculosis reported in France during 2005 under the mandatory reporting system. In 2005, the number of tuberculosis cases reported in France was 5,374, or 8.9 cases per 100,000 inhabitants. The reporting rate per 100,000 was less than 10 in all French regions, with the exception of Île-de-France and French Guiana (rates of 19.7/100,000 and 44.0/100,000, respectively). High reporting rates were observed in certain population groups, such as people born abroad (41.5 per 100,000), particularly those from sub-Saharan Africa (160 per 100,000) and those who had arrived in France less than two years prior (251 per 100,000), as well as homeless individuals (214 per 100,000) and people aged 80 and older (21.7 per 100,000). Pulmonary tuberculosis accounted for 73% of reported cases, 79% of which were contagious (pulmonary cases with positive microscopy or culture results). Data on reported tuberculosis cases in 2005 indicate a continued decline in incidence in France. However, the high incidence in certain population groups requires public health measures to be adapted to the needs of these populations, which are most at risk of tuberculosis. (R.A.)