Several meta-analyses of randomized controlled trials have shown that exercise programs focused on balance training and muscle strengthening can significantly reduce the rate of falls among older adults living at home, including those over 75 who are at higher risk. Recent data, including results from the French randomized controlled trial "Ossébo," indicate that exercise can also reduce traumatic falls (resulting in clinical symptoms and/or healthcare utilization), which are of greatest concern from a clinical and public health perspective. The type of program must be tailored to the age, as well as the health status and functional status of the target population, to be effective and acceptable in the long term. Home modifications, especially for those at higher risk, correction of vision problems, and gradual reduction of psychotropic medications are also effective in reducing falls. Multifactorial interventions based on an individual assessment followed by a set of preventive measures tailored to the person’s risk profile appear particularly well-suited for frail individuals and those at high risk of falling. In current practice, screening for a history of falls, supplemented by a simple balance and gait test, is recommended as the first step in systematic screening of older adults at risk of falling. Further (translational) research is now needed to determine the best strategies for increasing older adults’ participation in exercise programs and to successfully implement effective (evidence-based) programs and interventions in various settings.