Background: Currently, there is no reporting system in France capable of tracking work-related suicides, nor even those occurring in the workplace. A feasibility study on the implementation of a multi-source surveillance system for work-related suicides, based on existing data, was conducted by the Occupational Health Department of the French Institute for Public Health Surveillance. The objective of the system was to enable the counting and description of work-related suicides according to sociodemographic and occupational variables. Methods: The feasibility study was conducted in two stages: an exploratory phase to identify potentially usable data sources and a regional pilot study (Auvergne). Results: Four data sources were considered relevant for feeding the multi-source system: the CépiDc mortality database, compensation data from the main social security schemes, data from forensic medicine services, and data from the labor inspectorate. Conclusion: since none of the data sources is exhaustive, the pilot phase made it possible to identify work-related suicides in each source, and an overall number of cases was estimated. The feasibility study highlighted the limitations and success criteria for implementing such a system. Recommendations for the next steps were formulated, including collaboration with forensic medicine services, which hold essential data.