Controlling the spread of multidrug-resistant bacteria (MDRB) in healthcare facilities is a priority of the national program to combat healthcare-associated infections (HAIs). Since 2002, Raisin has coordinated surveillance of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-producing Enterobacteriaceae) isolated from diagnostic specimens in French HCFs. In 2012, 1,181 healthcare facilities participated in the surveillance program, representing a 147% increase since 2002. For MRSA, the overall incidence rate (IR) was 0.35 per 1,000 patient-days and ranged from 0.28 to 0.45 depending on the region. It was higher in short-stay units (0.46) and intensive care units (1.16) than in long-term care units (0.23). Since 2002, the MRSA ID has decreased by 44% overall and by 54% in intensive care units. For EBLSE, the overall IDR was 0.53 per 1,000 patient-days, ranging from 0.32 to 0.93 depending on the subregion. It was twice as high in short-stay care (0.71) as in SSR-SLD (0.32). Since 2002, the incidence of EBLSE has increased by 309%, and the proportion of Escherichia coli among EBLSE has risen from 19% to 59%. The decrease in MRSA incidence suggests a positive impact of the prevention measures implemented in the network’s participating departments. Finally, the increase in the incidence of EBLSE, particularly E. coli, is concerning and may serve as a potential reservoir for the emergence of new carbapenem-resistant strains. (R.A.)