An analysis of antibiotic use and prescribing in the outpatient sector was previously covered in an article in the 2021 issue of the BEH dedicated to antibiotic resistance. This article updates those findings. It confirms that antibiotic prescriptions are declining, but also shows that the impact of the COVID-19 pandemic on these prescriptions was limited to the year 2020. In 2021, a 4.9% increase in antibiotic consumption, expressed in defined daily doses (DDD), and a 6.2% increase in the number of prescriptions were observed. In 2022, these rates were even higher: 14% and 16.6%, respectively. However, these levels remain slightly below those of 2019. The results also confirm that trends vary by age. Thus, the sharpest decline in DDD consumption was among children aged five to fourteen, despite a very strong rebound in 2022. By limiting the spread of infectious diseases, preventive measures and lockdowns contributed to lower antibiotic prescribing in 2020. However, these factors played little role in 2021 and 2022. Preventive measures were relaxed or made optional, and a resurgence of winter illnesses was observed. These outbreaks contributed to the sharp increase in consumption at the end of 2022. Indeed, influenza-like illnesses were characterized in 2022–2023 by an exceptionally long epidemic. Similarly, a resurgence of bronchiolitis has been observed over the past two years. Against this backdrop of resurgence, strengthening the action programs implemented to promote the proper use of antibiotics and reduce their consumption remains more necessary than ever.