The Club Méditerranée resort in Serre Chevalier welcomes many guests, including children aged 4 months to 4 years (Baby Club), with a high turnover rate (1,100 people per week). During the winter of 2001–02, 241 cases of acute viral gastroenteritis (AVG), including 22 hospitalizations, were reported among the resort’s guests. An investigation and surveillance program were initiated to characterize the cases and identify potential risk factors. Weekly surveillance was conducted from 2002 to 2005, involving monitoring by the center and a network of general practitioners in Serre Chevalier. Two descriptive studies focused on the center’s clientele were conducted, as well as a study on prescriptions for VGE among residents of Serre Chevalier. The National Reference Center for Enteroviruses performed virus identification. Incidence rates were calculated among the vacation center’s clients and the resident population. The DDASS and the DDSV conducted environmental monitoring (drinking water and food service). Between the 2001–02 and 2005 winters, four outbreaks of acute gastroenteritis occurred among the center’s entire clientele, particularly in the Baby Club. All these outbreaks involved, to varying degrees, rotaviruses and caliciviruses. The first cases occurred after a 48-hour stay, corresponding to the incubation period of these viruses. During the outbreaks, the average weekly rates of acute gastroenteritis ranged from 60 to 100 per 1,000 children in the Baby Club and from 20 to 30 per 1,000 clients among the entire clientele. Food safety inspections did not identify any specific risks. The municipal water supply to the vacation center did not always meet microbiological standards, both outside of any outbreak and during 3 of the 4 GEA episodes. Neither the network of general practitioners nor the analysis of medication prescriptions detected an outbreak in the general population. These outbreaks particularly affected the Baby Club. This facility facilitated intense viral replication among non-immune and susceptible infants. Spread to the entire vacation center occurred through person-to-person transmission. Other factors may have contributed: self-service buffets, difficulties in disinfecting the premises, and municipal tap water that was often bacteriologically non-compliant. However, it appears that a specific operational model (frequent turnover and mixing of a large number of guests, a single-block building difficult to disinfect) combined with an early childhood care facility created conditions conducive to the development of these outbreaks. Anglo-Saxon guidelines for the prevention of viral AGE in tourist accommodations were difficult to implement. Only the discontinuation of infant care during the winter of 2004–05 appears to have had a decisive impact, with no outbreaks occurring in 2005–06.