Introduction - The national surveillance program for work-related diseases (WRD) was implemented in the Midi-Pyrénées region in 2006 to estimate the prevalence of WRD by sex, age, occupation, and economic sector. Method - This program relied on a sentinel network of volunteer occupational physicians who reported all observed cases of OW to the Regional Occupational Health Inspectorate over two consecutive weeks. The socio-professional characteristics of employees who underwent a medical examination during the period and the annual caseloads assigned to the physicians were also collected. Results - In Midi-Pyrénées, the prevalence of musculoskeletal disorders and mental distress was 3.7% and 1.3% among men, and 4.8% and 2.6% among women, respectively. Musculoskeletal disorders were more common among manual workers, whereas mental distress was more prevalent among professionals and middle-level workers. Mental distress was particularly high in the financial sector, and musculoskeletal disorders were particularly high in manufacturing, personal services among women, and construction among men. Discussion-Conclusion - This report has demonstrated the feasibility of a regional network of sentinel occupational physicians for the surveillance of work-related musculoskeletal disorders. The objective of this program aligns perfectly with the agenda of the Regional Health Conference. (R.A.)