This report presents data from French Guiana collected during the 2021 National Perinatal Survey, comparing it with data from metropolitan France. It describes the health status of mothers and newborns, their characteristics, medical practices during pregnancy and at the time of delivery, and the characteristics of delivery settings. The 2021 edition of the National Perinatal Survey (ENP) took place during the week of March 15–21, 2021, and included a 2-month follow-up for women who agreed to participate, making it possible to describe, for the first time, the health status of mothers two months postpartum, their childbirth experience, the organization of their return home, and the health status of their children during the first two months of life. This survey was funded and conducted by the Directorate General for Health (DGS), the Directorate General for Healthcare Provision (DGOS), the Directorate for Research, Studies, Evaluation, and Statistics (Drees), Santé publique France, and the Research Team in Obstetric, Perinatal, and Pediatric Epidemiology (EPOPé) of the National Institute of Health and Medical Research (Inserm). The follow-up of mothers and newborns at 2 months was led by Santé publique France. This report provides estimates of numerous perinatal indicators derived from an analysis of data collected from 128 women who gave birth to a live infant during the survey week conducted in the four maternity wards in French Guiana in March 2021. The percentages presented are based on small sample sizes and should be interpreted with caution (the confidence intervals are wide).