The Nancy University Hospital faced an outbreak of gastrointestinal colonization by G-resistant enterococci (G-resistant enterococci). In 2005, an initial wave of the outbreak was contained by strengthening hand hygiene practices, providing support to the teams dealing with the outbreak through the operational hygiene team, conducting practice audits and issuing reminders about the absolute necessity of applying specific “contact” precautions for all ERG+ patients and all “contact” patients, and finally by grouping ERG+ patients together. After a year of calm, the outbreak resumed in late 2006, but this time, only the exclusive promotion of hand rub disinfection with hydroalcoholic products, combined with the establishment of cohorting areas dedicated to the care of ERG+ patients (grouping patients in a unit that treats only ERG+ patients with healthcare staff caring exclusively for these patients), made it possible to bring the situation under control. Today, the facility must manage a large active caseload of ERG+ or formerly ERG+ patients, which requires maintaining an active cohorting unit. (R.A.)