When clubfoot (PVE) is detected during prenatal screening without any other associated fetal abnormalities, the question arises as to whether amniocentesis is indicated. The appropriate course of action is currently a matter of debate. The objective of this study is to evaluate the value of fetal karyotyping following prenatal screening for isolated VEF based on population data from two French registries of congenital malformations. All records of children with VEF identified by the registries between January 2000 and December 2004 were analyzed retrospectively. Only cases with prenatal screening for isolated clubfoot were included. During the study period, 653 children with clubfoot were identified, of whom 138 met the inclusion criteria. The fetal karyotype was verified for 42% of them. With more than 3 years of follow-up, the isolated nature of the VFF appears confirmed for 129 children, and minor anomalies were associated in 8 children. For 1 child, the fetal karyotype revealed partial trisomy 2, and the pregnancy was terminated. Recent published studies concluded that there is no significant association between isolated prenatal clubfoot and aneuploidy. With a risk of 1 in 138, it seems premature to conclude that the prenatal diagnosis of isolated clubfoot is not an indication for amniocentesis. Further analysis of the data over several years is necessary. (R.A.)