Dengue is currently the most widespread arbovirus disease in the world. Two-fifths of the world’s population—approximately 2.5 billion people—are now at risk. In 2001 alone, there were more than 609,000 cases of dengue in the Americas, including 15,000 cases of dengue hemorrhagic fever. The disease is now endemic in more than 100 countries in Africa, the Americas (including the Caribbean), the Eastern Mediterranean, Southeast Asia, and the Western Pacific. From an epidemic situation caused by the circulation of a single serotype, South America is gradually evolving toward a hyperendemic situation in which different serotypes will circulate continuously. In the coming years, we can likely predict a situation similar to that in Southeast Asia. Dengue hemorrhagic fever could then become one of the leading causes of hospitalization among children in South America. Since the arrival of hemorrhagic dengue in the Caribbean, Martinique has experienced three major epidemics, each linked to the circulation of one or two predominant serotypes: DEN-2 and DEN-1 in 1997, DEN-3 in 2001, and DEN-4 and DEN-2 in 2005. In March 2006, the simultaneous circulation of all four serotypes was observed for the first time in Martinique. This alarming situation reinforces the hypothesis of an impending permanent co-circulation of the four serotypes, which could lead to a worsening of dengue epidemics. Effective action is therefore urgently needed against this disease, whose outbreaks are becoming an almost annual risk for the French Departments of the Americas. The fight against dengue requires the coordinated participation of multiple complementary stakeholders in the fields of epidemiology, entomology, mosquito control, clinical medicine, biology, and public communication. The Program for the Surveillance, Alert, and Management of Dengue Epidemics (Psage Dengue) presented in this document thus pursues a twofold objective: - to formalize the roles and responsibilities that each partner involved in the fight against dengue undertakes to fulfill; - providing the necessary tools for carrying out the program’s various actions in the areas of epidemiological and entomological surveillance, mosquito control, communication, and patient care. The Psage Dengue aims to integrate epidemiological surveillance and public health response activities within the framework of the Program for Alert and Management of Health Emergencies (Pragsus). The development of epidemiological surveillance for dengue fever, with the aim of supporting the development of control and prevention programs, has been explicitly recommended by the Vector-Borne Diseases Division of the Centers for Disease Control and Prevention (CDC) in Fort Collins, Colorado. This approach, tested for dengue fever, should gradually be extended to other priority communicable diseases. Psage proposes a tiered approach to dengue surveillance and control strategies in Martinique, based on epidemic risk, as assessed from the results of epidemiological surveillance. The strategies to be implemented are organized into four main areas of activity: (1) Epidemiological and entomological surveillance and investigations; (2) Mosquito control (insecticide treatment and community mobilization); (3) Communication: informing healthcare professionals, political and administrative officials (Prefecture, DSDS, General Council, Mayors, Hospitals), and the general public; (4) Medical care provided by the healthcare system. In its current version, the Psage does not describe the routine mosquito control strategies implemented based on the results of entomological surveillance.