Two extended-spectrum cephalosporin resistant N. gonorrhoeae isolates were discovered among 6,342 (0.03%) French isolates between 2010 and 2014. One isolate corresponded to the F89 multidrug N. gonorrhoeae isolate harboring a penA mosaic; whole genome sequencing highlighted an additional R251H substitution in the ftsX gene recently involved in cephalosporin resistance. The other one ceftriaxone resistant isolate (MIC = 0.25 mg/liter) harbored the PBP2 pattern XXXVI plus a P551S substitution and belonged to the ST1579 (MLST).