Introduction: Heart failure (HF) is a common and serious condition in Western countries. Few epidemiological data are available. However, its prevalence is on the rise due to an aging population as well as improvements in the treatment of severe acute coronary events, the leading causes of HF. The objective is to estimate the annual rate of deaths from HF at the national and regional levels and to analyze trends between 2000 and 2010. Methods: Data were extracted from the national databases on medical causes of death maintained by the CépiDc. We considered mortality from HF among multiple causes. Rates were standardized to the 2006 French population, and trends were analyzed using Poisson regressions. Results: In 2010, the overall standardized mortality rate from HF was 96.8 per 100,000. It decreased by 30% between 2000 and 2010. Significant regional disparities existed, particularly between Nord-Pas-de-Calais (124.6/100,000) and Île-de-France (75.3/100,000). The decline was marked among men of all ages and among women aged 65 and older. Discussion-Conclusion: Despite a significant reduction in mortality between 2000 and 2010, heart failure remains a common cause of death in France, particularly among the elderly. Geographic disparities are likely linked to variations in the distribution of risk factors and in care. (R.A.)