Introduction: Cardiovascular diseases are the third leading cause of premature death in France. The objective of this study was to describe regional disparities in premature cardiovascular mortality for ischemic heart disease (IHD), cerebrovascular disease (CVD), heart failure (HF), and pulmonary embolism (PE) from 2008 to 2010, and to examine trends over time. Methods: Data were extracted from national databases of medical causes of death. For each condition, the average annual regional rates for 2008–2010 were standardized and then compared to the national rate. Their trends since 2000–2002 were analyzed using Poisson regressions. Results: Significant regional disparities were observed. The regions of Nord-Pas-de-Calais, Picardy, Upper Normandy, Champagne-Ardenne, Auvergne, and Limousin had higher rates of premature mortality than the national average for the four conditions considered. Premature mortality from CVD, PE, and HF was higher in the overseas departments than in mainland France. Since 2000–2002, premature mortality has decreased unevenly depending on the region and the condition. Discussion: Despite a decline in premature mortality from cardiovascular disease over the past decade, regional disparities persist. These are possibly linked to geographic variability in the main risk factors and in care. The respective contributions of these various factors remain to be determined. (R.A.)