Introduction: In France, stroke is the leading cause of death among women. However, stroke mortality rates declined between 2000 and 2006. Against the backdrop of significant changes in stroke care, this study describes trends in stroke mortality rates since 2008. Methods: Data were drawn from the national database of medical causes of death for the period 2008–2013. Crude mortality rates by age group and sex were calculated and then age-standardized. Trends over time were analyzed using Poisson regression. Results: In 2013, 31,346 deaths from stroke were recorded. Between 2008 and 2013, the stroke mortality rate decreased by 13.1%. This decrease was observed in both sexes and across all age groups, except for women aged 45 to 64 and individuals aged 85 and older. Significant regional disparities in mortality rates were observed in 2013, with rates varying by a factor of two. The four overseas regions, Hauts-de-France, and Brittany had the highest rates, while Île-de-France had the lowest. Conclusion: The decline in stroke mortality continues. However, further progress is still needed to ensure that as many stroke patients as possible receive early care. Finally, a decrease in stroke incidence among women aged 45–64 and an increase in their care in neurovascular units could help reduce mortality in this population.