Introduction: Stroke has long been underestimated in women, as it was generally considered a disease affecting men. It is now recognized as a major public health issue among women, on par with breast cancer, because its prevalence is significant and because its clinical, prognostic, etiological, therapeutic, and preventive aspects differ from those in men. Epidemiological data on stroke incidence and mortality rates among women remain scarce and controversial. The aim of this study was to compare, based on data from the three population registries of Dijon, Brest, and Lille, the incidence, attack, case fatality, and 28-day mortality rates of stroke in women and men over the age of 35. Methodology: This study is based on the prospective collection, from 2008 to 2012, of de novo and recurrent strokes included in three existing French population registries in Dijon (152,000 inhabitants) since 1985, in Brest (368,000 inhabitants) since 2007, and in Lille (228,000 inhabitants) since 2008. Incidence, attack, case fatality, and 28-day mortality rates were measured for ischemic, hemorrhagic, and stroke of undetermined origin, both overall by combining the three registries and specifically for each city, by age group, and for each year from 2008 to 2012. Results: Over the study period, 4,704 new-onset strokes and 1,307 recurrent strokes were recorded, representing 21% of the cohort. The overall annual incidence of all types of stroke, for both sexes combined, is 248/100,000/year in Dijon, 255/100,000/year in Brest, and 297/100,000/year in Lille, indicating the existence of a north-south gradient between Lille and Dijon and between Lille, Brest, and Dijon for women. This gradient is even more pronounced for stroke rates. Incidence rates are lower among women in all three cities and continue to decline over time in Lille and Brest, converging with the already low rates in Dijon. This gradual decline over time among women is linked to the decrease in the incidence of ischemic strokes. A higher 28-day case-fatality rate is observed among women, though not significantly so when the three cities are combined, associated with a significantly lower 28-day mortality rate among women across the three cities. Finally, a decline in 28-day mortality rates over time is observed only among women, though this is not statistically significant. This decline is not observed in men or for hemorrhagic strokes. Discussion: The relative consistency of incidence rates across the three cities validates the results published by the Dijon Stroke Registry since 1987, and the existence of a north-south gradient highlights the shared vascular risk factors with ischemic heart disease. The significant decline in incidence rates among women is good news and encourages further investigation into the factors driving this trend to understand why such a trend is absent among men and in hemorrhagic strokes. Conclusion: Despite the significant decline in incidence rates over time and the non-significant decline in 28-day stroke mortality rates among women, the aging of the female population in France will likely lead to a rapid increase in the prevalence of stroke among women in France.