The Aedes albopictus mosquito, a vector for dengue, chikungunya, and Zika viruses, has been present in mainland France since 2004. It poses a risk of local transmission of these arboviruses due to the regular introduction of the viruses by individuals who become infected while traveling to areas where these viruses circulate. In mainland France, epidemiological surveillance comprises two permanent national systems based on mandatory reporting (MR) and a network of laboratories, as well as a local enhanced surveillance system in departments where Ae. albopictus is present during its active season, estimated to run from May 1 to November 30. In 2016, in mainland France, 34 cases of chikungunya, 184 cases of dengue, and 781 cases of Zika virus infection were reported. The laboratory network identified 415 individuals with at least one positive laboratory test result for chikungunya, 723 for dengue, and 1,060 for Zika virus infection. From May 1 to November 30, 18 cases of chikungunya, 167 cases of dengue, 453 cases of Zika virus infection, 1 dengue-Zika co-infection, and 9 cases of flavivirus were confirmed in the 30 departments where Ae. albopictus was established. All were imported, with the exception of 3 autochthonous cases of Zika virus infection, which were transmitted sexually. The results of surveillance for these diseases in mainland France reflected the epidemiological situation in the travelers’ areas of origin. The Zika virus outbreak in the French territories of the Americas (TFA) had a major impact on the number of imported cases and, more generally, on surveillance in 2016. The risk of local transmission remains present in mainland France. It depends on the spread of Ae. albopictus and the international epidemiological situation. It is necessary to inform travelers going to or returning from risk areas, as well as healthcare professionals, so that they can relay prevention guidelines and participate in surveillance.