The Gay and Lesbian Media Survey (EPGL) is an anonymous, self-administered, voluntary cross-sectional study that was conducted again in 2011 through the media and community websites. The purpose of this article is to describe the characteristics of men who have sex with men (MSM) who have had at least one male casual partner in the past 12 months, as well as their preventive and harm reduction practices regarding HIV transmission and/or infection. To account for combination prevention, a matrix integrating various prevention and risk reduction practices was constructed using self-reported data on behaviors, serostatus, and whether or not HIV infection was being managed. A total of 10,448 MSM responded to the survey; 71% had had at least one casual partner in the past 12 months. Fourteen percent had never been tested for HIV; among those tested, 17% were HIV-positive, 69% were HIV-negative, and 14% were HIV-indeterminate. Consistent condom use during anal sex with casual partners was reported more frequently by HIV-negative respondents (58%). No harm reduction practices were observed among 25% of HIV-positive respondents, 16% of HIV-negative respondents, 55% of those with an unknown status, and 35% of those who had not been tested. The EPGL results demonstrate the adoption of HIV prevention practices by MSM, as well as variations in these practices based on HIV status and awareness of that status. Current levels of HIV testing and infection control appear insufficient to reverse the epidemic trend among MSM. (R.A.)