Introduction - In France, an estimated 40,000 people are unaware that they are infected with HIV. The use of rapid diagnostic tests (RDTs) could facilitate screening. This study evaluates the feasibility and acceptability of using RDTs, as well as their impact on the reporting of results at a free, anonymous screening center (CDAG). Patients and Methods - Between January 2010 and January 2011, a RDT was offered, along with an ELISA serological test, to all clients who reported that their last unprotected sexual encounter had occurred more than 3 months prior. Results - During the study period, 3,179 clients visited the CDAG; 2,448 RAPID tests were performed, of which 15 were positive (0.5%). The RAPID test result was reported to 97.6% of clients, whereas the reporting rate for ELISA serology tests was 78% the previous year. No false negatives were identified with the rapid test, and 2 of the positive rapid tests were not confirmed by ELISA; 79.3% of patients returned to retrieve all results of the serological tests performed during the initial consultation. Discussion-Conclusion - TRODs provide rapid results with good sensitivity and specificity. Further studies are needed to assess the value of using TRODs in populations unaware of their risks or located far from screening centers. (R.A.)