The use of invasive devices is associated with serious infections, particularly bacteremia and ventilator-associated pneumonia. These infections are a major cause of mortality and morbidity, and the care of infected patients results in additional costs. A strategy combining infection surveillance and rapid feedback of results, observation of practices, and training of healthcare professionals responsible for the placement and use of invasive devices can reduce infections related to these devices by up to 50%. Reducing the number of infections associated with invasive devices is a national priority enshrined in the national program for the prevention of healthcare-associated infections (PROPIAS). Under the authority of the Santé publique France agency, the National Mission for the Surveillance and Prevention of Infections Associated with Invasive Devices (SPIADI) has developed and is piloting a program aimed at reducing the incidence of infections associated with invasive devices. The program comprises three synergistic components: infection surveillance for three months each year across all healthcare sectors, an annual campaign to observe practices, and training. Here we report the main results of the second national surveillance survey of infections associated with invasive devices, which took place from January 1 to July 15, 2020.