The Comede Health Center at Bicêtre Hospital provides medical consultations to migrants living in the Île-de-France region who have recently arrived in France and are particularly vulnerable. A comprehensive health screening is routinely offered, including testing for HBV and HCV infections, and is completed by 96% of patients. Results are continuously documented by healthcare providers in a database and in a paper medical record. The prevalence of chronic HBV and HCV infection among 16,095 individuals seen in general medical consultations at the health center between 2007 and 2016 was 6.8% for HBV and 1.8% for HCV. Only 8% of those infected with HBV and 15% of those infected with HCV were already aware of their serostatus. Among those seen in 2014, 6% were vaccinated against HBV and 45% required catch-up vaccination. A higher accumulation of vulnerabilities is found among HCV-infected individuals, who tend to be older. These results support a proposal for screening using the three HBV markers and HCV antibodies, supplemented if necessary by catch-up vaccination or referral for follow-up and treatment. More generally, the goal is to improve access to care and prevention among migrants with multiple risk factors.