Objectives: As part of the implementation of an epidemiological surveillance system for the Air France industrial sector, the objectives were (i) to analyze the causes of death among employees in comparison to the general French population, and (ii) to compare employee mortality according to their occupational characteristics. Methods: Using personnel records, all employees who were active for at least 365 days between 1968 and 2007 were identified, along with their occupational category (agent, technician, supervisor, manager) and their job title. After obtaining vital status and the initial cause of death, overall mortality and mortality by cause were compared to that of the general French population by calculating standardized mortality ratios (SMR) and their 95% confidence intervals [95% CI]. The relative risk (RR) of death and its 95% CI by occupational category and job were estimated using Cox models. Results: Mortality follow-up of the 22,299 men and 1,978 women in the study identified 4,371 deaths (4,222 among men and 149 among women). A lower mortality rate was observed compared to the general population (SMR=0.77 among men and SMR=0.75 among women). In contrast, a 70% excess of deaths from malignant melanoma was observed among men (SMR=1.70 [1.08–2.55]; 23 observed deaths versus 14 expected). Survival analysis shows that 50% of individuals were still alive at age 80. A social gradient in mortality is observed, with a higher risk of death for those who worked the longest as laborers compared to managers (RR=1.50 [1.33-1.68]). Conclusion: implementing an epidemiological approach at the company level is both possible and useful. This provides the company with quantified and objective data on the health status of its employees. The identification in our study of a higher risk of death from malignant melanoma among men led to the implementation of specific prevention measures (awareness campaigns on sun-related risks, screening days).