Introduction: Genitourinary infections, including prostatitis, are thought to increase the risk of prostate cancer due to the chronic inflammation they may cause. We investigated the association between various genitourinary infections and the risk of developing prostate cancer (PC) using data from the EPICAP study. Methods: EPICAP is a case-control study conducted in the general population of the Hérault department between 2012 and 2014. A total of 819 incident cases and 879 controls were included. Established or suspected risk factors for PC, as well as personal history of genitourinary infections (prostatitis, urethritis, orchi-epididymitis, acute pyelonephritis), were collected using a standardized questionnaire during an individual interview. Odds ratios (OR) and their 95% confidence intervals were estimated using unconditional logistic regression. Results: Overall, 139 (18%) cases and 98 (12%) controls reported having at least one personal history of a genitourinary infection (OR=1.64 [1.23–2.20]). This risk increased with the number of infections (p-trend <0.05). A personal history of chronic prostatitis and acute pyelonephritis more specifically increased the risk of developing PCa (OR=2.95 [1.26–6.92] and OR=2.66 [1.29–5.51], respectively). Conclusion: Our results support the hypothesis that chronic inflammation, resulting from a history of genitourinary infections, may play a role in prostate carcinogenesis.