Introduction: Early exposure to endocrine disruptors, which are ubiquitous in the environment, may affect the development of reproductive functions. Idiopathic central precocious puberty (ICP) is one of the conditions that may be affected in women. The feasibility of establishing an epidemiological surveillance system enabling spatial and temporal analyses of ICP based on medical-administrative databases (MADs) was investigated. Methods: For metropolitan France, an ICP indicator was constructed for each MAD studied: first hospitalizations for ICP based on PMSI-MCO hospitalization data (2004–2012); first prescriptions of GnRH agonists based on DCIR-Sniiram medication consumption data (2011–2012); first-time reports of PCCI based on long-term conditions (ALD) data. Results: The PMSI-MCO indicator reflects all suspected cases of PCCI evaluated in the hospital: 40% of diagnosed cases are treated. The DCIR-Sniiram indicator allows for the nearly exhaustive identification of treated cases, whether the diagnosis is made in the community or in the hospital. The ALD indicator reflects approximately 30% of children treated for PPCI. Discussion: The indicator related to first-time drug prescriptions appears particularly well-suited for monitoring PPCI and its trends. The limitations associated with possible variations in medical practices across regions and over time require further investigation. Furthermore, the use of DCIR-Sniiram data enables an analysis of spatial variations at the municipal level. (R.A.)