Introduction: The United Nations Climate Change Conference (COP21) brought together delegations from around the world in France, with 20,000 delegates from 195 countries in attendance each day, including 150 heads of state during the first 48 hours. A specialized medical response was organized in the unique “post-attack” context, facing significant constraints due to the establishment of a zone under the sole authority of the UN (Blue Zone). Objective: To assess the medical resources deployed and the care provided. Methods: Medical response managed by SAMU 93 in collaboration with the regional SAMU and the Regional Health Agency (ARS) for the entire site, including the Blue Zone. Evaluation criteria: personnel deployed, number of consultations, and evacuations (including medical evacuations). Results: In the “France Zone” (operational command post): one dispatch physician and one assistant for 20 days. In the “Blue Zone”: 20 first responders, a 24/7 medical team (SMUR), and two emergency physicians (consultations) on duty 12 hours a day for 16 days. In total, 47 physicians, 25 nurses, 25 SMUR paramedics, and 20 assistants participated in the medical response. This corresponded to three full-time equivalent (FTE) emergency physicians over 16 days. Consultations performed: 1,238, or 97 per day, resulting in 34 (3%) evacuations, including seven medical evacuations. There were 706 (57%) male patients and 495 (43%) female patients, with a mean age of 43 ± 1 years. Traumatology was the most common condition (20%). Conclusion: Significant medical resources were deployed over the 16-day period. Medical activity was sustained, but medical evacuations were rarely required.